B06 - SABRE hyperpolarization to quantify low concentration metabolites for early disease diagnosis

B06 develops a new platform for metabolomic classification in body fluids and its application. At its core, this platform is based on compact high-field NMR, while the sensitivity enhanced by parahydrogen hyperpolarization. The platform operates on a three-step process: preparation of a body fluid equivalent; parahydrogen-based hyperpolarization; sensitive NMR detection. While the platform itself is designed for generalized metabolite detection at low concentrations, special emphasis is placed on a target system (urine-based detection of analytes indicative of an infection with tuberculosis).

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